Graphene Oxide-Based Injectable Conductive Hydrogel Dressing with Immunomodulatory for Chronic Infected Diabetic Wounds | Semantic Scholar (2024)

FAQs

What are hydrogels for diabetic wounds? ›

Hydrogel dressings are composed of three-dimensional networks of water-absorbing polymers that can hold a large amount of water and maintain a moist wound environment. This moist environment promotes wound healing by facilitating cell migration, promoting angiogenesis, and reducing inflammation.

The hydrogel provides moisture which enables painless debridement of necrotic and infected tissue, promotes granulation and encourages complete healing. Since they have a high water content, they are not completely absorbent, which makes them appropriate for wounds with light to moderate exudation.

Silicone Foam Dressings

These tend to do a much better job at protecting the area and keeping the wound site hydrated, creating an optimal healing environment. These come in many forms, including hydrogel, collagen, etc. But the dressings most often associated with diabetic wounds are silicone foam dressings.

Hence, hydrogels derived from chitosan can promote the healing of wounds as well as the prevention of infection. Recently, an injectable carboxymethyl chitosan (CMCS) hydrogel to modulate cellular responses and facilitate the complete recovery of diabetic wounds was developed.

Contraindications. There are two types of wounds for which a hydrogel dressing is not advised — full-thickness burns and moderate- to high-exuding wounds.

However, hydrogels are reported the best choice compared to other dressing forms due to they have the needed requirements for the ideal wound dressings (Table 1). The only disadvantage of hydrogels is their poor mechanical stability at swollen state.

Amorphous hydrogels are applied liberally onto or into a wound and covered with a secondary dressing such as foam or film. Hydrogels can remain in situ for up to 3 days. Hydrogels are indicated in dry, sloughy wounds with mild exudate, partial thickness wounds.

Hydrogels are recommended for wounds that range from dry to mildly exudating and can be used to degrade slough on the wound surface. Hydrogels have a marked cooling and soothing effect on the skin, which is valuable in burns and painful wounds.

Hydrogels' soft consistency, porosity, and high water content are very similar to natural living body tissue, making them critical components in general medical applications. Hydrogel wound dressings promote healing, provide moisture, and offer pain relief with their cool, high water content.

What is a hydrogel treatment? ›

Hydrogels offer excellent biocompatibility, biodegradability, drug loading and controlled release of drugs and are widely used in cancer radiotherapy, chemotherapy, immunotherapy, hyperthermia, photodynamic therapy and photothermal therapy (Figure 1).