Graphene Oxide-Based Injectable Conductive Hydrogel Dressing with Immunomodulatory for Chronic Infected Diabetic Wounds | Semantic Scholar (2024)
14 Citations
Hydrogels Containing Chitosan-Modified Gold Nanoparticles Show Significant Efficacy in Healing Diabetic Wounds Infected with Antibiotic-Resistant Bacteria
Hongqi MengYing ZhaoWenrui Qu
Medicine, Materials Science
International journal of nanomedicine
2024
In the diabetic wound model rats, Gel/CS-AuNPs effectively killed MRSA, reduced inflammation, and promoted angiogenesis and collagen deposition and remodeling at the wound site, which expedited the recovery process for infected diabetic wounds.
Preparation and evaluation of oxidized-dextran based on antibacterial hydrogel for synergistic photodynamic therapy.
Yuting ZhaoPeiyong GuoLiang Liu
Medicine, Chemistry
International journal of biological…
2023
1
3D printed alginate/gelatin-based porous hydrogel scaffolds to improve diabetic wound healing
Zhaoyi LinWeike XieZhenhua CuiJiana HuangHao CaoYan Li
Medicine, Engineering
Giant
2023
2
PTT/ PDT-induced Microbial Apoptosis and Wound Healing Depend on Immune Activation and Macrophage Phenotype Transformation.
Haoyu ChenLijuan WuJinsheng Shi
Medicine, Environmental Science
Acta biomaterialia
2023
6
Multifunctional conductive hyaluronic acid hydrogels for wound care and skin regeneration.
Víctor Castrejón-ComasC. AlémanM. M. Pérez‐Madrigal
Medicine, Materials Science
Biomaterials science
2023
The most advanced research undertaken to engineer conductive and interactive hydrogels based on HA as wound dressings that enhance skin tissue regeneration either through electrical stimulation (ES) or by displaying multifunctional performance is presented.
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51 References
Immunoregulation in Diabetic Wound Repair with a Photoenhanced Glycyrrhizic Acid Hydrogel Scaffold
Yuna QianYujing ZhengJianliang Shen
Medicine, Materials Science
Advanced materials
2022
A novel glycyrrhizic acid (GA)‐based hybrid hydrogel dressing with intrinsic immunoregulatory properties is developed to promote rapid diabetic wound healing and serve as a promising dressing for the management of diabetic wounds.
183
Thermosensitive Hydrogel Incorporating Prussian Blue Nanoparticles Promotes Diabetic Wound Healing via ROS Scavenging and Mitochondrial Function Restoration.
Zhao XuYujing LiuTongkai Chen
Medicine, Materials Science
2022
The resultant PBNPs@PLEL wound dressing was able to improve diabetic wound healing, decrease ROS production, promote angiogenesis, and reduce pro-inflammatory interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) levels within diabetic wounds.
Treatment with miR-155-inhibitor-loaded MSC-derived exosomes led to enhanced collagen deposition, angiogenesis, and re-epithelialization in diabetic wounds and opened the doors for encapsulating miRNAs along with antibiotics within the M SC-derivedExosomes toward improved management of chronic, nonhealing diabetic wounds.
37
Pharmacodynamic and immunomodulatory effects of polymyxin B in combination with fosfomycin against KPC-2-producing Klebsiella pneumoniae.
Rajnikant SharmaEstefany GarciaG. Rao
Medicine
International journal of antimicrobial agents
2022
4
Infection Micromilieu‐Activated Nanocatalytic Membrane for Orchestrating Rapid Sterilization and Stalled Chronic Wound Regeneration
Xiong ZhouZiyue WangYi Deng
Medicine, Materials Science
Advanced Functional Materials
2021
In vivo assays demonstrate that the nanocatalytic membranes reshape the stalled chronic wound into a regenerative wound by massacring bacteria, stopping bleeding, boosting epithelialization/collagen deposition of the wound beds, and promoting angiogenesis.
51
Novel supramolecular self-healing silk fibroin-based hydrogel via host–guest interaction as wound dressing to enhance wound healing
Rui YuYutong YangJiahui HeMeng LiBaolin Guo
Materials Science, Medicine
2021
106
Rescuing the Last-Line Polymyxins: Achievements and Challenges
S. NangM. AzadT. VelkovQ. ZhouJian Li
Medicine
Pharmacological Reviews
2021
A comprehensive overview on the major achievements and challenges in polymyxin pharmacology and clinical use and how the recent findings have been employed to improve clinical practice worldwide is provided.
148
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Enhanced wound repair ability of arginine-chitosan nanocomposite membrane through the antimicrobial peptides-loaded polydopamine-modified graphene oxide
Chuan FuZhiping QiXiaoyu Yang
Materials Science, Medicine
Journal of biological engineering
2021
Together, this study not only prepared a wound dressing with excellent tissue repair ability, but also provided a novel idea for the development of graphene oxide-based antibacterial dressing.
22
PDF
A pulsatile release platform based on photo-induced imine-crosslinking hydrogel promotes scarless wound healing
Jian ZhangYongjun ZhengXiaoyang Wu
Medicine, Materials Science
Nature Communications
2021
The authors develop a wound dressing material based on an integrated photo-crosslinking strategy and a microcapsule platform with pulsatile release of TGF-β inhibitor to achieve spatiotemporal specificity for scarless wound repair.
130
PDF
Highly Stretchable, Adhesive, Biocompatible, and Antibacterial Hydrogel Dressings for Wound Healing
Zifeng YangR. HuangHui Wang
Medicine, Materials Science
Advanced science
2021
The multifunctional hydrogels show stable covering, little displacement, long‐lasting antibacterial property, and fast wound healing, demonstrating promise in wound dressing.
Hydrogel dressings are composed of three-dimensional networks of water-absorbing polymers that can hold a large amount of water and maintain a moist wound environment. This moist environment promotes wound healing by facilitating cell migration, promoting angiogenesis, and reducing inflammation.
The hydrogel provides moisture which enables painless debridement of necrotic and infected tissue, promotes granulation and encourages complete healing. Since they have a high water content, they are not completely absorbent, which makes them appropriate for wounds with light to moderate exudation.
These tend to do a much better job at protecting the area and keeping the wound site hydrated, creating an optimal healing environment. These come in many forms, including hydrogel, collagen, etc. But the dressings most often associated with diabetic wounds are silicone foam dressings.
Hence, hydrogels derived from chitosan can promote the healing of wounds as well as the prevention of infection. Recently, an injectable carboxymethyl chitosan (CMCS) hydrogel to modulate cellular responses and facilitate the complete recovery of diabetic wounds was developed.
Contraindications. There are two types of wounds for which a hydrogel dressing is not advised — full-thickness burns and moderate- to high-exuding wounds.
However, hydrogels are reported the best choice compared to other dressing forms due to they have the needed requirements for the ideal wound dressings (Table 1). The only disadvantage of hydrogels is their poor mechanical stability at swollen state.
Amorphous hydrogels are applied liberally onto or into a wound and covered with a secondary dressing such as foam or film. Hydrogels can remain in situ for up to 3 days. Hydrogels are indicated in dry, sloughy wounds with mild exudate, partial thickness wounds.
Hydrogels are recommended for wounds that range from dry to mildly exudating and can be used to degrade slough on the wound surface. Hydrogels have a marked cooling and soothing effect on the skin, which is valuable in burns and painful wounds.
Hydrogels' soft consistency, porosity, and high water content are very similar to natural living body tissue, making them critical components in general medical applications. Hydrogel wound dressings promote healing, provide moisture, and offer pain relief with their cool, high water content.
Hydrogels offer excellent biocompatibility, biodegradability, drug loading and controlled release of drugs and are widely used in cancer radiotherapy, chemotherapy, immunotherapy, hyperthermia, photodynamic therapy and photothermal therapy (Figure 1).
Introduction: My name is Pres. Lawanda Wiegand, I am a inquisitive, helpful, glamorous, cheerful, open, clever, innocent person who loves writing and wants to share my knowledge and understanding with you.
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