Graphene Oxide-Based Injectable Conductive Hydrogel Dressing with Immunomodulatory for Chronic Infected Diabetic Wounds | Semantic Scholar (2024)

14 Citations

Hydrogels Containing Chitosan-Modified Gold Nanoparticles Show Significant Efficacy in Healing Diabetic Wounds Infected with Antibiotic-Resistant Bacteria
    Hongqi MengYing Zhao Wenrui Qu

    Medicine, Materials Science

    International journal of nanomedicine

  • 2024

In the diabetic wound model rats, Gel/CS-AuNPs effectively killed MRSA, reduced inflammation, and promoted angiogenesis and collagen deposition and remodeling at the wound site, which expedited the recovery process for infected diabetic wounds.

Conductive electrospun nanofiber based on silk fibroin/cellulose nanocrystals/reduced graphene oxide as a wound healing material
    B. MassoumiRaana SarvariE. Fakhri

    Materials Science, Medicine

    International Journal of Polymeric Materials and…

  • 2024
Hierarchical double-layer microneedles accomplish multicenter skin regeneration in diabetic full-thickness wounds.
    Xiaoqi HuangXingtang Niu Qiang Chang

    Medicine, Engineering

    Journal of advanced research

  • 2024
  • PDF
Biodegradable pectin-based thermo-responsive composite GO/hydrogel with mussel inspired tissue adhesion for NIR enhanced burn wound healing
    Yanai ChenLimin Chang Jianglei Qin

    Engineering, Medicine

    Chemical Engineering Journal

  • 2023
Electrospun fibers based anisotropic silk fibroin film with photodynamic antibacterial therapy for S. aureus infected wound healing.
    Jiaying LiShuxuan ZhangChang HeJue Ling

    Medicine, Materials Science

    International journal of biological…

  • 2024
  • 1
Thou shall not heal: Overcoming the non-healing behaviour of diabetic foot ulcers by engineering the inflammatory microenvironment.
  • 2
  • PDF
Preparation and evaluation of oxidized-dextran based on antibacterial hydrogel for synergistic photodynamic therapy.
    Yuting ZhaoPeiyong Guo Liang Liu

    Medicine, Chemistry

    International journal of biological…

  • 2023
  • 1
3D printed alginate/gelatin-based porous hydrogel scaffolds to improve diabetic wound healing
    Zhaoyi LinWeike XieZhenhua CuiJiana HuangHao CaoYan Li

    Medicine, Engineering


  • 2023
  • 2
PTT/ PDT-induced Microbial Apoptosis and Wound Healing Depend on Immune Activation and Macrophage Phenotype Transformation.
    Haoyu ChenLijuan Wu Jinsheng Shi

    Medicine, Environmental Science

    Acta biomaterialia

  • 2023
  • 6
Multifunctional conductive hyaluronic acid hydrogels for wound care and skin regeneration.
    Víctor Castrejón-ComasC. AlémanM. M. Pérez‐Madrigal

    Medicine, Materials Science

    Biomaterials science

  • 2023

The most advanced research undertaken to engineer conductive and interactive hydrogels based on HA as wound dressings that enhance skin tissue regeneration either through electrical stimulation (ES) or by displaying multifunctional performance is presented.

  • 10



51 References

Immunoregulation in Diabetic Wound Repair with a Photoenhanced Glycyrrhizic Acid Hydrogel Scaffold
    Yuna QianYujing Zheng Jianliang Shen

    Medicine, Materials Science

    Advanced materials

  • 2022

A novel glycyrrhizic acid (GA)‐based hybrid hydrogel dressing with intrinsic immunoregulatory properties is developed to promote rapid diabetic wound healing and serve as a promising dressing for the management of diabetic wounds.

  • 183
Thermosensitive Hydrogel Incorporating Prussian Blue Nanoparticles Promotes Diabetic Wound Healing via ROS Scavenging and Mitochondrial Function Restoration.
    Zhao XuYujing Liu Tongkai Chen

    Medicine, Materials Science

  • 2022

The resultant PBNPs@PLEL wound dressing was able to improve diabetic wound healing, decrease ROS production, promote angiogenesis, and reduce pro-inflammatory interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) levels within diabetic wounds.

  • 65
Mesenchymal Stem Cell-Derived Exosomes Loaded with miR-155 Inhibitor Ameliorate Diabetic Wound Healing.
    Piyush GondaliyaA. A. Sayyed K. Kalia


    Molecular pharmaceutics

  • 2022

Treatment with miR-155-inhibitor-loaded MSC-derived exosomes led to enhanced collagen deposition, angiogenesis, and re-epithelialization in diabetic wounds and opened the doors for encapsulating miRNAs along with antibiotics within the M SC-derivedExosomes toward improved management of chronic, nonhealing diabetic wounds.

  • 37
Pharmacodynamic and immunomodulatory effects of polymyxin B in combination with fosfomycin against KPC-2-producing Klebsiella pneumoniae.
    Rajnikant SharmaEstefany Garcia G. Rao


    International journal of antimicrobial agents

  • 2022
  • 4
Infection Micromilieu‐Activated Nanocatalytic Membrane for Orchestrating Rapid Sterilization and Stalled Chronic Wound Regeneration
    Xiong ZhouZiyue Wang Yi Deng

    Medicine, Materials Science

    Advanced Functional Materials

  • 2021

In vivo assays demonstrate that the nanocatalytic membranes reshape the stalled chronic wound into a regenerative wound by massacring bacteria, stopping bleeding, boosting epithelialization/collagen deposition of the wound beds, and promoting angiogenesis.

  • 51
Novel supramolecular self-healing silk fibroin-based hydrogel via host–guest interaction as wound dressing to enhance wound healing
    Rui YuYutong YangJiahui HeMeng LiBaolin Guo

    Materials Science, Medicine

  • 2021
  • 106
Rescuing the Last-Line Polymyxins: Achievements and Challenges
    S. NangM. AzadT. VelkovQ. ZhouJian Li


    Pharmacological Reviews

  • 2021

A comprehensive overview on the major achievements and challenges in polymyxin pharmacology and clinical use and how the recent findings have been employed to improve clinical practice worldwide is provided.

  • 148
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Enhanced wound repair ability of arginine-chitosan nanocomposite membrane through the antimicrobial peptides-loaded polydopamine-modified graphene oxide
    Chuan FuZhiping Qi Xiaoyu Yang

    Materials Science, Medicine

    Journal of biological engineering

  • 2021

Together, this study not only prepared a wound dressing with excellent tissue repair ability, but also provided a novel idea for the development of graphene oxide-based antibacterial dressing.

  • 22
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A pulsatile release platform based on photo-induced imine-crosslinking hydrogel promotes scarless wound healing
    Jian ZhangYongjun Zheng Xiaoyang Wu

    Medicine, Materials Science

    Nature Communications

  • 2021

The authors develop a wound dressing material based on an integrated photo-crosslinking strategy and a microcapsule platform with pulsatile release of TGF-β inhibitor to achieve spatiotemporal specificity for scarless wound repair.

  • 130
  • PDF
Highly Stretchable, Adhesive, Biocompatible, and Antibacterial Hydrogel Dressings for Wound Healing
    Zifeng YangR. Huang Hui Wang

    Medicine, Materials Science

    Advanced science

  • 2021

The multifunctional hydrogels show stable covering, little displacement, long‐lasting antibacterial property, and fast wound healing, demonstrating promise in wound dressing.

  • 255
  • PDF



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    Graphene Oxide-Based Injectable Conductive Hydrogel Dressing with Immunomodulatory for Chronic Infected Diabetic Wounds | Semantic Scholar (2024)


    What are hydrogels for diabetic wounds? ›

    Hydrogel dressings are composed of three-dimensional networks of water-absorbing polymers that can hold a large amount of water and maintain a moist wound environment. This moist environment promotes wound healing by facilitating cell migration, promoting angiogenesis, and reducing inflammation.

    How are hydrogels used in wound healing? ›

    The hydrogel provides moisture which enables painless debridement of necrotic and infected tissue, promotes granulation and encourages complete healing. Since they have a high water content, they are not completely absorbent, which makes them appropriate for wounds with light to moderate exudation.

    What is the best dressing for a diabetic wound? ›

    Silicone Foam Dressings

    These tend to do a much better job at protecting the area and keeping the wound site hydrated, creating an optimal healing environment. These come in many forms, including hydrogel, collagen, etc. But the dressings most often associated with diabetic wounds are silicone foam dressings.

    Does hydrogel promote wound healing? ›

    Hence, hydrogels derived from chitosan can promote the healing of wounds as well as the prevention of infection. Recently, an injectable carboxymethyl chitosan (CMCS) hydrogel to modulate cellular responses and facilitate the complete recovery of diabetic wounds was developed.

    When should you not use hydrogel dressing? ›

    Contraindications. There are two types of wounds for which a hydrogel dressing is not advised — full-thickness burns and moderate- to high-exuding wounds.

    What are the disadvantages of hydrogel dressing? ›

    However, hydrogels are reported the best choice compared to other dressing forms due to they have the needed requirements for the ideal wound dressings (Table 1). The only disadvantage of hydrogels is their poor mechanical stability at swollen state.

    How long can hydrogel dressing stay on? ›

    Amorphous hydrogels are applied liberally onto or into a wound and covered with a secondary dressing such as foam or film. Hydrogels can remain in situ for up to 3 days. Hydrogels are indicated in dry, sloughy wounds with mild exudate, partial thickness wounds.

    What kind of wound is hydrogel good for? ›

    Hydrogels are recommended for wounds that range from dry to mildly exudating and can be used to degrade slough on the wound surface. Hydrogels have a marked cooling and soothing effect on the skin, which is valuable in burns and painful wounds.

    What is an example of a hydrogel wound dressing? ›

    Table 2
    ComfeelColoplastDesigned for difficult-to-dress areas
    CovaWoundCovalonPressure, leg and foot ulcers, superficial partial-thickness burns
    InadineSystagenixOpen wounds that may become infected
    SofargenSofarFor abrasions, grazes, first- and second-degree burns and injuries
    9 more rows
    Aug 11, 2020

    Why are hydrogel dressings used? ›

    Hydrogels' soft consistency, porosity, and high water content are very similar to natural living body tissue, making them critical components in general medical applications. Hydrogel wound dressings promote healing, provide moisture, and offer pain relief with their cool, high water content.

    What is a hydrogel treatment? ›

    Hydrogels offer excellent biocompatibility, biodegradability, drug loading and controlled release of drugs and are widely used in cancer radiotherapy, chemotherapy, immunotherapy, hyperthermia, photodynamic therapy and photothermal therapy (Figure 1).

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